comparison of the effect of adjuvant 5-fluorouracil, low molecular weight heparin and daunomycin in combination with triamcinolone during vitrectomy in advanced retinal detachment
نویسندگان
چکیده
purpose: to compare the success rate of adjunctive 5-fluorouracil (5-fu) and low molecular weight heparin (lmwh), and daunomycin in combination with triamcinolone during vitrectomy in eyes with retinal detachment (rd) and proliferative vitreoretinopathy (pvr). methods: in this prospective randomized clinical trial, 69 eyes from 69 patients with rd and pvr (grade b or c) randomized to 3 groups. group 1: received 5-fu and lmwh (200 microgram/ml 5-fu and 5 iu/ml lmwh, fragmin) group 2: received daunomycin (0.5 mg) in 500 cc infusion fluid and group 3: control group. in all patients, 0.1 cc intravitreal triamcinolone was used during vitrectomy. the patients visited on day 1, week 1, month 1, 3 and 6. best corrected visual acuity (bcva) and retinal status compared in the 3 groups. results: complete data were available for 60 out of 69 patients. thirty five patients (58.3%) were male and 25 patients (41.7%) were female. the patient age range was 19-84 years and the mean age was 49. the groups did not have significant difference in age, sex, duration of detachment, severity of pvr, preoperative visual acuity (v/a), lens status, type of tamponade and encircling band and buckle. postoperative v/a and retina status also was the same in the 3 groups. conclusion: perioperative infusion of 5-fu, lmwh and daunomycin does not significantly increase the success rate of patients with rd and pvr comparing to control group. although visual acuity improvement and retina reattachment rate in group 1 and 2 were better than control group, but statistical analysis failed to show significant difference between the 3 groups. iranian journal of ophthalmology 200820(1):42-47
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عنوان ژورنال:
journal of current ophthalmologyجلد ۲۰، شماره ۱، صفحات ۴۲-۴۷
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